Antibiotic Tissue Penetration



Blood Brain Barrier: Penicilins (IV), 3rd & 4th generation Cephalosporins (IV), Meropenem, TMP-SMX, Metronidazole, Linezolid, Fluoroquinolones

Prostate: Fluoroquinolones

Urine: Beta-lactams, Fluoroquinolones (NOT moxifloxacin), TMP-SMX, Aminoglycosides

Lungs:  Most antibiotics EXCEPT Daptomycin (inactivated by pulmonary surfactant), Aminoglycosides (hydrophilic, low Vd), Vancomycin (low Vd)

Intrabdominal: Beta-lactams, Ceftriaxone

Bone: Fluoroquinolones

Poor Abscess Penetration: Aminoglycoside (inactivated by low pH)



Ashley & Brooke Barlow PharmD @theABofPharmaC



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