Ashley Barlow

Blood Pressure Targets in Hypertensive Crisis Timeline: 1 hour: ↓ MAP by 25%, Maintain DBP ≥ 100 mmHg 2-6 hours: Titrate To Goal SBP 160 mmHg & DBP 100 mmHg 24 hours: Maintain SBP <160 mmHg & DBP <100 mmHg Ashley & Brooke Barlow PharmD @theABofPharmaC #Blood #Pres

Status Epilepticus Pharmacotherapy Guide • Phenytoin and Fosphenytoin • Valproate Sodium • Levetiracetam • Lacosamide • Midazolam • Phenobarbital • Propofol • Ketamine Ashley & Brooke Barlow PharmD @theABofPharmaC #Status #Epilepticus #Phar

Status Epilepticus Pharmacology Ashley & Brooke Barlow PharmD @theABofPharmaC #Status #Epilepticus #Pharmacology #neurology #management #seizure

High Dose Methotrexate - Toxicities and Pharmacology Ashley & Brooke Barlow PharmD @theABofPharmaC #High #Dose #Methotrexate #Pharmacology #oncology #leucovorin #Toxicities

Antithrombotic Regimens for Prosthetic Heart Valves Mechanical Heart Valves Bioprosthetic Heart Valves Transcatheter Aortic Valve Repair Ashley & Brooke Barlow PharmD @theABofPharmaC #anticoagulation #Prosthetic #Heart #Valves #replacement #mechanical #pharmacology #ca

Testicular Cancer - Treatment Related Toxicities Bleomycin, Cisplatin, Etoposide, lfosfamide Tinnitus & Hearing Loss Neurotoxicity Pulmonary Fibrosis Hypotension Nephrotoxicity Skin Hyperpigmentation Hemorrhagic Cystitis Myelosuppression Peripheral Neuropathy Ashle

Antibiotic Tissue Penetration Blood Brain Barrier: Penicilins (IV), 3rd & 4th generation Cephalosporins (IV), Meropenem, TMP-SMX, Metronidazole, Linezolid, Fluoroquinolones Prostate: Fluoroquinolones Urine: Beta-lactams, Fluoroquinolones (NOT moxifloxacin), TMP-SMX, Aminogly

Pharmacologic Management of ARDS Acute Respiratory Distress Syndrome (ARDS) - Berlin Definition Mechanical Ventilation - Minimizing "Baro trauma" Fluid Management in ARDS - Liberal vs. Conservative Approach Corticosteroids in ARDS Neuromuscular Blockade Pulmonary Vasodila

Rasburicase Pharmacology Summary Recombinant urate oxidase from saccharomyces Immediate onset of action Dosing: - Package insert: 0.2 mg/kg IV once daily up to 5 days - Clinical practice: 1.5-6mg x 1 dose depending on the level of uric acid Contraindications: G6PD defic

Allopurinol Pharmacology Summary Xanthine oxidase inhibitor blocking the formation of new uric acid Initiate 1-2 days prior to chemotherapy Dosing: 100 mg/m2/dose every 8 hours (max 800mg/day) • Usual: 300 mg/day • Dose adjustments for CrCl <10mL/min Side effects: g

Cyclophosphamide Pharmacology Summary Mechanism of Action: Alkylating Agent Indications: Solid tumors, Breast. bladder, endometrial. ovarian, testicular, osteosarcoma Toxicities - Hemorrhagic Cystitis Ashley & Brooke Barlow PharmD @theABofPharmaC #Cyclophosphamide #Pha

Amphotericin B - Pharmacology Summary Sheet Class: Polyene Antifungal Mechanism of Action: • Binds to ergosterol → Complexes and intercalate into cell membrane → pore formation and leakage of intracellular contents → cell apoptosis Pharmacokinetics: • Conce

Atrioventricular (AV) Blocks First Degree AV Block - "If your R is far from your P than you have a first degree" • 1:1 conduction with prolonged PR interval (>200 msec) • P wave preceding each QRS complex • Site of Block: Delayed conduction at the AV node Second

Dihydropyridine Calcium Channel Blockers Mechanism of Action: L-Type calcium channel blockade - Inhibits the influx of calcium into smooth muscle resulting in coronary and peripheral vasodilation Indications: Angina (with rate controlling agent), vasospastic angina, raynauds

Delirium in the ICU Defining delirium Types of delirium Consequences of delirium Reversible causes of delirium Drug-induced delirium Non-pharmacologic management of delirium Pharmacologic management of delirium Ashley & Brooke Barlow PharmD @theABofPharmaC #ICU #De