Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia

Induction: 

 • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate

Consolidation & CNS protection:

 • IT methotrexate, Vincristine, Steroid, Thiopurine

Interim and continuing maintenance therapy:

 • Monthly vincristine and pulsed (5 days), steroid (dexamethasone), Daily 6-mercaptopurine, Weekly oral methotrexate, Prophylactic co-trimoxazole is given throughout treatment (after induction) to prevent Pneumocystis carinii pneumonia, IT methotrexate

Delayed intensification:

 • Vincristine, Dexamethasone, Doxorubicin, L-Asparaginase, IT methotrexate, Cyclophosphamide, Cytarabine



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