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Tapentadol is a prescription medication used to manage moderate to severe pain. It works by acting on two mechanisms: it stimulates opioid receptors in the brain (like traditional opioids) and inhibits the reuptake of norepinephrine, a neurotransmitter. This dual action differentiates it from many other painkillers, making it effective for both nociceptive (physical injury) and neuropathic (nerve-related) pain. It is typically prescribed when other pain relievers, such as non-opioid medications, are not effective or appropriate. Tapentadol is available in both immediate-release (for acute pain) and extended-release (for chronic pain) formulations.

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