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Tapentadol is a prescription pain reliever classified as an opioid analgesic. It's commonly used to treat moderate to severe pain, such as pain from surgery or injury, and can also be prescribed for chronic pain conditions like osteoarthritis or neuropathic pain. Tapentadol works by binding to opioid receptors in the brain and inhibiting norepinephrine reuptake, thereby altering the way the brain and nervous system respond to pain. Tapentadol has a dual mechanism of action, combining opioid receptor agonism and norepinephrine reuptake inhibition. This makes it distinct from other opioids. It is available in both immediate-release and extended-release formulations.

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