Causes of Hypocomplementemia - CHAMPS Mnemonic

C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis

H - Heavy Chain deposition disease, hereditary angioedema

A - Atypical HUS, autoimmune (RA, Sjogren's), antiphospholipid syndrome, atheroembolic, AIHA

M - Membranoproliferative glomerulonephritis, type 1 (50%-80%), type II (80-90%)

P - Post/pauci immune glomerulonephritis (>90%)

S - Systemic Lupus Erythematosus (total 50, renal 75-90%), subacute bacterial endocarditis (90%)



- Dr. Ann Marie Kumfer @AnnKumfer



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