Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury

Hepatocellular Liver Injury

 • AST/ALT elevation > Alk phos

 • ALT more specific for hepatic pathology (low level of expression in skeletal muscle and kidney)

Is it a Hepatocellular or Cholestatic Liver Injury? 

 • R value = (ALT + ULN ALT) / (alkaline phosphatase + ULN alkaline phosphatase)

     R ≥ 5 = Hepatocellular injury

     R ≤ 2 = Cholestatic injury



 - Ann Marie Kumfer @AnnKumfer



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