Polyuria - Differential Diagnosis Algorithm

Urine Output > 3L /day

Water Diuresis (Urine Osm <100 mOsm/kg)

 • Primary Polydipsia

 • Central Diabetes Insipidus

 • Nephrogenic Diabetes Insipidus

Mixed Diuresis (Urine Osm 100-200 mOsm/kg)

 • Water and solute loading

 • Relief of prolonged urinary obstruction

 • Partial Dl

 • Chronic Renal Failure

Solute Diuresis (Urine Osm 300-500 mOsm/kg)

 • Hyperglycemia

 • Azotemia

 • Exogenous solute load



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