Hypercalcemia - Hormones and Pathophysiology  

Calcitriol:

 • Bones: Enhances mineralization

 • GI Tract: ↑ Ca2+ absorption, ↑ PO4- absorption

 • Kidneys: ↑ Ca2+ reabsorption, ↑ PO4- reabsorption

 • Serum: ↑ Ca2+, ↑ PO4- 

PTH:

 • Bones: ↑ Bone resorption (↑ Ca2+ and ↑ PO4- release)

 • Kidneys: ↑ Ca2+ reabsorption, ↓ PO4- reabsorption

 • Serum: ↑ Ca2+, ↓ PO4- 

Calcitonin:

 • Bones: ↓ Bone resorption (↓ Ca2+ and ↑ PO4- release)

 • GI Tract: ↓ Ca2+ absorption

 • Kidneys: ↑ Ca2+ reabsorption, PO4- reabsorption

 • Serum: ↓ Ca2+, ↓ PO4- 



#Hypercalcemia #Hormones #Pathophysiology #endocrinology