Systemic Lupus Erythematosus - Summary

Antinuclear (ANA) - 95% - Initial screening test

Anti-dsDNA - 50%

 • Associated with more severe disease & renal involvement

 • Used to monitor disease activity

Anti-Ro/SSA - 40%

 • Associated with skin manifestations

 • Neonatal SLE, including congenital heart block

 • Sjogren syndrome

Anti-UI-ribonucleoprotein - 35%

 • Raynaud phenomenon & esophageal dysmotility

 • MCTD (SLE/systemic sclerosis/polymyositis overlap syndrome)

Anti-Smith - 25%

 • Specific for SLE. Associated with more severe disease

Treatment:

 • Mild disease- Hydroxychloroquine

 • Moderate disease - Hydroxychloroquine *Short course of steroids +/- methotrexate or azathioprine

 • Severe disease- high dose steroid+ mycophenolate, azathioprine, cyclophosphamide or rituximab



Dr. Ann Marie Kumfer @AnnKumfer



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