IDSA Recommendations for Treating Herpes Simplex Virus (HSV) Infections in HIV-AIDS

Treating Orolabial Lesions (Duration: 5–10 days)

 • Valacyclovir 1 g PO BID or

 • Famciclovir 500 mg PO BID or

 • Acyclovir 400 mg PO TID 

Treating Initial or Recurrent Genital Lesions (Duration: 5–10 Days)

 • Valacyclovir 1 g PO BID or

 • Famciclovir 500 mg PO BID or

 • Acyclovir 400 mg PO TID

Treating Severe Mucocutaneous HSV Infections:

 • Initial therapy acyclovir 5 mg/kg IV q8h

 • After lesions begin to regress, change to oral therapy as above.

 • Continue treatment until lesions have completely healed.



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