IDSA Suggested Empiric Antibiotic Regimens Based on Clinical Severity for Diabetic Foot Infections

Mild (usually treated with oral agent[s])

 • Staphylococcus aureus (MSSA); Streptococcus spp

 • Methicillin-resistant S. aureus (MRSA)

Moderate (may be treated with oral or initial parenteral agent[s]) or severe (usually treated with parenteral agent[s])

 • MSSA; Streptococcus spp; Enterobacteriaceae; obligate anaerobes

 • MRSA

 • Pseudomonas aeruginosa

 • MRSA, Enterobacteriacae, Pseudomonas, and obligate anaerobes



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