PDE5 inhibitors are usually the drugs of first choice for erectile dysfunction.



PDE5 inhibitors enhance an erection that is partially developing as a result of effective sexual stimulation and mental sexual arousal. 



Drug interactions with PDE5 inhibitors include alpha blockers and CYP3A4 inhibitors - which can be used concomitantly with caution - e.g. at lower doses. PDE5 inhibitors should not be used with nitrates due to serious and potentially fatal hypotension - and should be separated by 12 - 48 hours (depending on the drug).

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