Causes of Fever: IMADE Mnemonic

INFECTION

 • Infection 1.0 - Common & Localizing: Base Rate

 • Infection 2.0 - Beyond The Base Rate: Tick-Borne. Fungal, TB, etc.

MALIGNANCY

 • Leukemia & Lymphoma >> Solid Cancers +/- Hepatic Metastases

 • Pearl: 20% of renal cell carcinomas present with fever!

AUTOIMMUNE

 • SLE

 • Adult-Onset Stills Disease

 • Schnitzler

 • GPA

 • Vasculitides

 • Myosites

DRUGS

 • SJS-TEN: lamotrigine, valproate. carbamezapine, sulfa drugs, aminopenicillins. allopurinol, oxicam NSAlDs

 • DIHS: allopurinol. carbamezapine. lamotrigine. phenytoin. sulfasalzine. vancomycin, minocycline, dapsone. sulfamethoxazole

 • NMS: neuroleptics, antipsychotics

 • Others: antihistamines. amphetamines, hydralazine. methyldopa. antithyroids

DVT/PE

 • Thrombosis leads to increased inflammtory cytockines (IL-I, IL-6, IL-8, TNF-alpha)! Heparin itself has anti-inflammatory properties. and avoid premature closure with DVT/PE + fever.

ENDOCRINE

 • Most commonly associated with hyperthyroidism. Also think about subacute thyroiditis, adrenal insufficiency, or pheochromocytoma



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