Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm

Decreased WBCs

 - Decreased/NormaI Reticulocytosis

     • Marrow Aplasia

     • Marrow Infiltration

 - Increased Reticulocytosis

     • Primary Hypersplenism

     • Secondary (e.g. RA, SLE, PRV, Chronic)

Normal/lncreased WBCs

 - Polychromatic Macrocytes, Normal RBCs

     • Acute Bleed

     • Hemolysis

 - Polychromatic Macrocytes, RBC Spherocytes, RBC Fragments

     • Microangiopathic Hemolytic Anemias (MAHA)

 - Abnormal RBCs - Sickle Cells, Target Cells

     • Hemoglobinopathy

 - Normal Reticulocytosis

     • Renal Failure

     • Inflammation

     • Cancer

     • Hypothyroid

     • Pregnancy

     • Early Iron Deficiency



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