Causes of Fatigue - Differential Diagnosis Algorithm

Endocrine

 • Hypo/Hyperthyroidism

 • Diabetes

 • Pituitary Insufficiency

 • Adrenal Insufficiency 

Metabolic

 • Renal Failure

 • Liver Failure

 • Hypercalcemia

Neoplastic / Hematologic

 • Anemia

 • Malignancy

Infectious

 • Endocarditis

 • Tuberculosis

 • Epstein-Barr

Virus

 • Hepatitis

 • HIV

Autoimmune / Inflammatory

 • Rheumatoid Arthritis

 • SLE

 • Polymyalgia Rheumatica

Cardiopulmonary

 • Congestive Heart Failure

 • Chronic Obstructive Pulmonary Disease

Neurologic

 • Depression

 • Multiple Sclerosis

 • Stroke

 • Parkinson's

 • Myasthenia Gravis

Pharmacologic

 • Hypnotics

 • Anti-hypertensives

 • Anti-Depressants

 • Drug Abuse (e.g. Alcohol)

 • Drug Withdrawal

Psychogenic

 • Anxiety

 • Somatization Disorder

 • Malnutrition / Drug Addiction 

Idiopathic

 • Chronic Fatigue Syndrome



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