Skin Ulcers by Etiology - Differential Diagnosis Algorithm

Physical:

 • Trauma

 • Pressure

 • Radiation

Vascular:

 • Arterial Insufficiency

 • Venous insufficiency

 • Vasculitis

Neoplastic:

 • Squamous cell carcinoma

 • Basal cell carcinoma

 • Melanoma

 • Mycosis fungoides (cutaneous T-cell lymphoma)

Neurological:

 • Diabetic neuropathy

 • Tabes dorsalis (syphilis)

 • Factitious disorder

 • Delusions of parasitosis

Metabolic:

 • Pyoderma gangrenosum

 • Diabetic dermopathy

 • Necrobiosis lipoidica

Drugs:

 • Coumadin

 • Heparin

 • Bleomycin

Hematologic:

 • Sickle Cell Anemia

 • Thalessemia

 • Cryoglobulinemia

Infectious:

 - Protozoan - Leishmaniasis

 - Viral - Herpes simplex

 - Bacterial

     • Tuberculosis

     • Syphilis

     • Chlamydia trachomatis

     • Klebsiella granulomatis

 - Fungal

     • Histoplasmosis

     • Coccidioidomycosis

     • Cryptococcosis



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