Mucous Membrane Disorder - Differential Diagnosis Algorithm

Erosions/Ulcers/Blisters

 - Primary Dermatologic Diseases

     • Aphthous Stomatitis (recurrent, punched out ulcers, often preceded by trauma/emotional stress)

     • Herpetic gingivostomatitis

     • Pemphigus vulgaris

     • Bullous pemphigoid

     • Erythema multiforme

     • Stevens-Johnson Syndrome

     • Toxic epidermal necrolysis

 - Systemic Disease

     • Systemic lupus erythematosus

     • Inflammatory bowel disease (ulcerative colitis more than Crohn's disease)

     • Behcet's syndrome

White Lesions

 - Neoplastic

     • Leukoplakia

     • Squamous cell carcinoma

 - Candidiasis - White/cottage cheese like plaques/scrape off easily

 - Lichen Planus - Reticular (lace-like) white lines & papules



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