Hypophosphatemia - Differential Diagnosis Algorithm
Transcellular Shift
• Recovery From DKA
• Refeeding Syndrome
• Acute Respiratory Alkalosis
• Hypokalemia
• Hypomagnesemia
• Burns
Increased Excretion - GI:
• Small bowel diarrhea
• Enteric Fistula
Increased Excretion - Renal FE PO4 > 5%:
• Hyperparathyroidism
• Vitamin D Deficiency/Resistance
• Hypophosphatemic Rickets
• Oncogenic Osteomalacia
• Fanconi Syndrome
• Osmotic Diuresis
• Acute Volume Expansion
• Acetazolamide and Thiazide Diuretics
Decreased Intake - Dietary deficiency:
• Anorexia
• Chronic Alcoholism
Decreased Intake - Malabsorption:
• Aluminum/Magnesium Containing Antacids
• Inflammatory Bowel Disease
• Steatorrhea
• Chronic Diarrhea
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