Fever of Unknown Origin (FUO) - Further Workup



 • CNS symptoms? Get an LP and imaging of head/spine

 • Returning traveler?  Refer to your ‘Fever in a Returning Traveler’ algorithm

 • Travel to Midwest or Southeast?  Test for the respective fungal pathogens based on geography

 • Travel to malaria–endemic regions?  Thick and thin smear

 • Signs of VTE?  Venous duplex or CTA

 • Liver lesions?  Liver biopsy

 • Lymphadenopathy?  Lymph node biopsy

 • Clinical findings of PAN?  Temporal artery biopsy

 • Lab values supporting hematologic malignancies?  Bone marrow biopsy



Dr. Uday Gulati @udaygulati



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