Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
• Enzyme deficiencies ex. G6PD, pyruvate kinase
• Hemoglobinopathies ex. SCD, thalassemias
• Membrane defects ex. Hereditary spherocytosis / elliptocytosis
Extrinsic Causes:
• Liver disease
• Hypersplenism
• AIHA: warm, cold, drug induced
• Infections ex. Bartonella, Babesia, Malaria
• Oxygen agents ex. dapsone, nitrates
• Other agents ex. lead, copper, spider/snake bites
• IVIG infusion
Intravascular Causes:
• MAHA: TTP, HUS, DIC, HELLP, AS, prosthetic valve
• Transfusion reactions ex. ABO incompatibility
• Paroxysmal Nocturnal Hemoglobinuria
• S/p IV infusion of Rhogam
• S/p IV infusion of hypotonic solutions
Dr. Uday Gulati @udaygulati
#Hemolytic #Anemia #Differential #Diagnosis #causes #classification #hematology