Pathophysiology of Tumor Lysis Syndrome (TLS)

Tumor Cell Lysis

-> Release of DNA

 • Purines -> Hypoxanthine / Xanthine -> Uric Acid (low urinary excretion) -> Allantoin (High urinary excretion)

 • Phosphorus -> Ca-Phos Precipitation

=>

 • Urate Nephropathy (low urine pH)

 • Ca-Phos nephropathy (high urine pH)

 • Hypocalcemia

 • Hyperkalemia



#TumorLysis #Syndrome #TLS #Pathophysiology #UricAcid