Hypocalcemia - Differential Diagnosis Algorithm - Low and High PTH

LOW PTH - Hypoparathyroid

 - Congenital (Pediatric)

    • Ca-S-R

    • DiGeorge

 - Acquired

    • Post-operative neck

    • Radiation

    • Infiltrative disease

    • Autoimmune polyendocrinopathy

    • Hypomagnesemia



HIGH PTH

 - 25-OH D very low

    • Malabsorption

    • Short gut

    • Gastric bypass

    • Liver disease

    • Increased Vit-D degradation (eg. anti-convulsants)

 - 25-OH D not very low

    • Chronic Renal Failure

    • Severe hyperphosphatemia (eg. Tumor lysis syndrome, rhabdomyolysis, oral phosphate abuse/laxatives)



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