Anaphylaxis: Signs and Symptoms

Anaphylaxis: when any egg of three conditions is met:

1. Acute onset of skin/mucosal involvement with 2 1 of'

    • respiratory compromise

    • hypotension

2. Rapid onset of symptoms after exposure to a likely allergen with >2 of:

    • skin/mucosal symptoms

    • respiratory symptoms

    • hypotension

    • persistent GI symptoms

3. Hypotension after exposure to known allergen

Note: Severity of symptoms in the acute phase does not necessarily predict occurrence of late phase symptoms

Signs / Symptoms / Complications:

 • Abdominal cramping, vomiting, diarrhea

 • Wheezing, dyspnea, hypoxia

 • Angioedema

 • Flushing

 • Hypotension -> Circulatory collapse ->

    - Neurological Compromise (e.g. syncope, seizures)

    - Cardiac Compromise (e.g. arrythmias, ischemia)

 • Urticaria

 • Angioedema



#Anaphylaxis #pathophysiology #immunology #diagnosis #signs #symptoms