Inflammatory Cascade: Pathogenesis and Clinical Findings

Continued Innate Immunity

 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf foreign pathogens and dead tissue

 • Complement System: opsonize pathogen (tag for destruction), promote inflammation

 • Natural Killer Cells: perforin-mediated wall breakdown (puncture holes), enzyme-mediated destruction

Acquired Immunity Recruitment

 • Humoral: (B cell response) production of antibodies, activation of complement system

 • Cell-mediated: (T cell response) Increased helper cell and cytotoxic cell activity



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