Aqueous Humor Production and Drainage

 • Provides nutrition, removes wastes, and transports neurotransmitters to the avascular lens and cornea.

 • Circulates inflammatory cells to avascular structures 

 • Maintains structural integrity of ocular structures via intraocular pressure (10-21 mmHg)



AH leaves the anterior chamber via two pathways located near the limbus:

 • Trabecular Meshwork Pathway (~60-80 % of flow) -> AH passes through the TM layers: Uveal, corneoscleral, and juxtacanalicular -> Flows into Schlemm's Canal -> Flows through internal outflow channels into the external outflow channels, aqueous veins, intrascleral venous plexus, and the deep scleral venous plexus -> Drains into the episcleral and conjunctival veins -> Drains back into systemic venous circulation

 • Uveoscleral Pathway (~20-40 % of flow) -> AH enters uveal meshwork and anterior ciliary body -> Flows in suprachoroidal space -> Passes outward through the sclera -> Enters the scleral, and conjunctival veins -> Drains back into systemic venous circulation



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