Alcohol Use Disorder: Pathogenesis and Clinical Findings



 • Tolerance (reduced sensitivity to effects of EtOH)

 • Social Impairment

    - Failure to fulfill role obligations (work, school, home)

    - Continued use despite social problems exacerbated by EtOH

    - Important social, occupational, recreational activities reduced

 • Risky Substance Use

    - Recurrent use of alcohol in hazardous situations

    - Continued use despite knowledge of consequences

 • Impaired Control 

    - Incr in alcohol consumption

    - Unsuccessful attempts to reduce alcohol use

    - Incr in time spent pursuing / using / recovering from EtOH

    - Alcohol craving - Intense desire to use EtOH

 • Withdrawal symptoms

    - Sweating, tachycardia, nausea/vomiting, tremor, insomnia, seizure, and anxiety



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