Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings

 • Impaired joint protection -> abnormal joint movements -> Incr ROM, joint instability, ligamentous laxity over time

 • Joint mounts an inflammatory response -> Local swelling, warmth, & erythema, joint effusion, pain (variable dependent on degree of denervation)

 • Inflammatory cytokines act on osteoclasts to promote periarticular bone resorption -> On X-ray: osteopenia

 • Joint progresses from minor deformity -> major deformity -> Visibly abnormal joint: joint subluxation

 • Destruction of articular cartilage -> On X-ray: joint space narrowing

 • Inability to move joint, Interference with movement of limb -> Inability to ambulate: unsteady, antalgic gait



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