Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE)



49M +burning rash groins/buttocks (pic in next thread) x 1d. No fever. 120/80,HR87. Exam: b/l warm,red patch groins/buttocks; no oral/palm lesion. WBC: 9. PMH: DM (A1c 6.5%; on canagliflozin), HTN (amlodipine), taking amox for a recent ear infection. Tx of this condition?

68% got the right answer, d/c culprit drug +/- steroids. The MCQ highlights a case of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). 

SDRIFE is a drug reaction uniquely characterized by:

 - symmetrical, well-demarcated,  erythematous, confluent maculopapular rash/plaques in the upper/inner thighs, inguinal, gluteal areas

Other features of SDRIFE:

 - also known as baboon syndrome (rash in the buttocks resembles that of baboons)

 - the rash can rarely exhibit pustules, blisters, or purpura 

 - does not involve the palms/soles, face, or mucosal surfaces



WuidQ: Washington University ID Questions @WuidQ



#SDRIFE #Symmetrical #DrugRelated #Intertriginous #Flexural #Exanthema #rash #clinical #photo #dermatology