REBEL Review 99: Serotonin Syndrome via Yosuf Alam, MSIV



Presentation: Altered mentd status, Seizures, Myoclonus, Hypertension, Hyperthermia (most common cause of death), Hyperreflexia, Muscle rigidity (Lower extremity Upper extremity)



Diagnosis: Clinical! No confirmatory lab tests

Cornerstone of treatment is discontinuing all serotonergic drugs and providing appropriate supportive care:

• IV fluid hydration; evaluation for rhabdomyolysis

• External cooling measures for hyperthermia



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