Digoxin effect on Electrocardiogram (EKG)

Digoxin is a cardiac glycoside from the foxglove leaf

Mechanism

 - Inhibits Na-K ATPase -> increase intracellular Na / extracellular K -> increase intracellular Ca -> increase contractility

 - Decreases AV nodal conduction

Uses:

 - Atrial fibrillation and atrial flutter (rate control)

 - Heart failure (syrnptom reduction) - not first Iine

Digoxin effect on ECG (at therapeutic level):

 - Scooping ST depression (Salvador Dali mustache)

 - Flag inverted or biphasic T waves

 - Short QT interval



Dr. Loran Hatch



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