Biphasic Illness of Leptospirosis

Some patients do not progress to severe disease. Others, rapidly develop severe disease w/o brief interval symptom improvement.

Septicemic phase (5-14 days):

 • Fever

 • Headache

 • Myalgia (esp. calf tenderness)

 • Conjunctival suffusion (redness w/o exudate)

 • Pretibial maculopapular rash

 • Others: nausea, vomiting, abdominal pain, diarrhea, cough

Immune phase (4-30 days):

 • Aseptic meningitis 

 • Weil's disease (renal + hepatic dysfunction)

 • Pulmonary hemorrhage

 • ARDS

 • Shock and multi-organ failure



- WuidQ: Washington University ID Questions @WuidQ



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