Ipilimumab-Induced Hypophysitis. 

Pituitary gland enlargement occurs on therapy & resolves after therapy.

 - Ipilimumab is a monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4, and adverse events may occur due increased T-cell activation.

 - Clinically, patients can develop anterior hypopituitarism.

 - On imaging, pituitary enlargement is the main finding, while stalk thickening can also be seen.

 - Resolves after therapy.

 - History of drug therapy important to not mistake for a metastasis.



Dr. Mark Mamlouk @ https://twitter.com/MarkMamloukMD



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