Dyspnea - Considerations with Malignancy

Directly Malignancy Related:

 - Lymphangitic spread to lung

 - Malignant pleural effusion

 - Malignant pericardial effusion

 - Lung metastases



Treatment Related:

 - Chemotherapy pneumonitis

 - Cardiomyopathy (anthracycline)

 - Hemorrhagic myocarditis (cyclophosphamide)

 - Coronary Vasospasm (cepecitabine)

 - Radiation pneumonitis

 - Radiation induced disease of:

    - Heart valves

    - Pericardium

    - Coronary arteries

    - Conduction system

 - Therapy-related malignancy

 - Cytopenias (anemia)



Changes in Pre-Test Probability:

 - Immunosuppression —> atypical bugs

 - Hypercoagulable -> PE



Based On: https://www.nejm.org/doi/full/10.1056/NEJMcps1414168



#dyspnea #algorithm #differential #diagnosis #oncology #cancer #malignancy