Consensus Indications for Irradiated RBC Transfusions:



Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused T lymphocytes can engraft, proliferate & attack the host.



 - Congenital cellular immunodeficiency disorders (DiGeorge Syndrome, Severe Combined Immunodeficiency Disorder, etc.) 

 - Intrauterine and neonatal transfusions up to four months of age 

 - Patients with Hodgkin Lymphoma 

 - Patients treated with immunosuppressive therapy (Alemtuzumab, antithymocyte globulin, etc.) 

 - Hematopoietic stem cell transplant patients, both autologous and allogeneic 

 - Individuals receiving HLA-selected products (e.g., HLA-matched, HLA-"compatible", or crossmatched platelets) 

 - Individuals receiving blood donations from first- or second-degree relatives 



Daniela Hermelin, MD @HermelinDaniela



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