Fibrates - Gemfibrozil and Fenofibrate 

Mechanism: activates PPAR alpha

Lipid Effects:

 - Decrease TG by 30-50%

 - Increase HDL by 5-15% 

 - Decrease LDL by 0-20% 



The Fibrate drug class includes gemfibrozil and fenofibrate. These 2 medications were very commonly used to treat dyslipidemia, specifically hypertriglyceridemia since it has great triglyceride lowering. It's very important to remember not to use either of these medications with a statin, as this increases the risk of rhabdomyolysis.



Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx



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