Insulin Degludec (Tresiba) vs Insulin Glargine (Lantus, Basaglar, or Toujeo)



Insulin degludec (Tresiba) is an ultra-long acting insulin that lasts up to 42 hours. Insulin glargine (Lantus, Basaglar, Toujeo) has been the standard basal insulin but degludec is become more and more frequently used. Major reasoning is that since it lasts longer, degludec never needs to be dosed BID while some patients do require BID dosing with glargine if it does not last the full 24 hours. Additionally, results from the DEVOTE trial demonstrated that degludec was noninferior in terms of CV outcomes and A1c lowering, but had significantly less incidence of severe hypoglycemia.



Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx



#Insulin #Degludec #Glargine #Comparison #Pharmacology #DEVOTE #Diabetes