GLP-1 Agonists



Adlyxin (Lixisenatide) Daily

Bydureon (Exenatide ER) Weekly 

Ozempic (Semaglutide) Weekly 

Trulicity (Dulaglutide) Weekly 

Victoza (Liraglutide) Daily

 

GLP-1 Agonists are commonly used medications to treat Type 2 Diabetes. They are subcutaneous injections, so many patients mistaken these medications for insulin. However, GLP-1's are very different. They work primarily on lowering post-prandial blood glucose due to the incretin effect. Some additional benefits include weight loss and carrying only a low risk of hypoglycemia. Common side effects include GI upset (since it works in the GI tract) and injection site pain.

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Depending on the product, it can be injected once daily or just once weekly! There is an ORAL GLP1 that is currently being studied (semaglutide), and we hope to see that come to market in the future. Notice that the MOA seems very similar to DPP4s from one of my previous posts. That's because they work in the same pathway, so it's important NOT to use them together since there’s no added benefit.



#GLP1 #Agonists #Pharmacology #Dosing #Diabetes #DM2 #Endocrinology



Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx