The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes:



Conditions with Abnormal RBCs:

 • Abnormal RBC 

 • Spherocytosis 

 • Sickle cells

 • Hemoglobin C

 • Xerocytosis

 • RBC agglutination



Situations where plasma opacification leads to a falsely elevated Hgb:

 • Hyperlipidemia 

 • Hemolysis (i.e., free hemoglobin)



- Dr. Tony Breu @tony_breu



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