Renal involvement in 35% of mixed cryoglobulinemia vasculitis 

Associated with : 

 • Absence of skin lesions 

 • Absence of peripheral neuropathy 

 • Type II cryoglobulinemia 

 • Combined decr of C3 and C4 levels 



Characteristics at presentation 

 • Hematuria - 97%

 • Mean proteinuria - 3.5 g/day (%)

 • > 3g / day - 49% 

 • Hypertension (%) - 85%

 • Mean eGFR - 39.5 mL/min

 • <60 mL/min/1.73m2 - 82%

 • Dialysis (%) - 5%



Factors associated with ESRD at last follow-up 

 • eGFR ml/min/1.73 m2 at diagnosis 

 • Dialysis at diagnosis 

 • Extracapillary proliferation 

 • Tendency for nephrotic range proteinuria



Dr. Benjamin Terrier @ https://twitter.com/TerrierBen



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