Acute Kidney Injury (AKI) in Patients with Cancer 



Cancer Related 

• Hypercalcemia 

• Intravenous contrast 

• Lymphomatous infiltration 

• Light chain (LC) cast nephropathy 

• LC deposition disease (LCDD) 

• Heavy chain DD 

• Proximal LC tubulopathy 

• Monoclonal gammopathy of renal significance (MGRS) 

• Secondary Membranous nephropathy 

• Solid tumors 

• Secondary Minimal change disease 

• Hematologic malignancies 



Treatment Related 

• Sepsis, volume depletion 

• Hepatic sinusoidal obstructive syndrome 

• Capillary leak syndrome (Interleukin-2) 

• Tumor lysis syndrome 

• Proximal tubular injury 

• Cisplatin 

• ATN: Imatinib, ifosfomide 

• Crystal nephropathy: Methotrexate 

• AIN: Sorafenib, sunitinib , PD-Ii 

• TMA: Gemcitabine, cisplatin, bevacizumab (VEGFi), TKi 

• Hemorrhagic cystitis -> bladder outlet obstruction (cyclophosphamide) 



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