Serotonin Syndrome

 - Rapid onset 

 - Combination of 2+ serotonin agonists 

Mental status changes: 

 - Agitation 

 - Pressured speech 

Autonomic instability:

 - Tachycardia 

 - Diarrhea 

 - Shivering 

 - Diaphoresis 

 - Mydriasis 

Neuromuscular abnormalities:

 - Clonus 

 - Hyperreflexia (lower > upper) 

 - Tremor 

 - Seizure 

Rx:

 - Benzodiazepines 

 - Hydration/Cooling 

 - Cyproheptadine 



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