Characteristics of Commonly Used Phosphate Binders 

Aluminum 

 - Potent and effective 

 - Useful for short term in severe hyperphosphatemia 

Calcium salt based 

 - Effective 

 - Inexpensive 

 - Treats hypocalcemia 

 - Antacid properties useful for reflux and peptic ulcer disease 

Sevelamer 

 - Effective 

 - No systemic absorption 

 - Lowers level of low-density lipoprotein cholesterol 

 - Lower risk of hypercalcemia 

 - Reduces aortic and coronary calcification versus calcium salts 

 - Lower risk of adynamic bone disease versus calcium salts 

Lanthanum carbonate 

 - Potent and effective over wide pH range 

 - Lack of hypercalcemia 

 - No evidence of increased risk of low bone turnover disease 

 - Reduced pill burden 

Ferric citrate 

 - Effective 

 - Significant absorption of iron that may decrease iron and ESA requirements 

 - Lack of hypercalcemia 

Sucroferric oxyhydroxide 

 - Potent and effective over wide pH range 

 - Lack of hypercalcemia 

 - No significant systemic absorption 

 - Reduced pill burden 



Dr. Edgar V. Lerma @edgarvlermamd - Nephrology Secrets https://amzn.to/34t5DgJ



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