Sulfonamides - Antibiotics Class Overview


BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic

Spectrum: Wide spectrum including typical bacterial pathogens – Gram positives (S.aureus including most CA-MRSA, some S.pneumo), and most Gram negatives but not Pseudomonas.  Notable highlights that set it apart from other agents are: activity vs Pneumocystis jiroveci, Nocardia, Toxoplasmosis, Listeria, Isospora, and Stenotrophomonas.
Used for: Many purposes including PCP PNA (drug of choice, both for treatment and prophylaxis), Community-acquired MRSA Skin infections, UTIs, Nocardiosis, Listeria infections in PCN-allergic patients, Salmonella infections, Traveler’s diarrhea, acute bronchitis, and otitis media.


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