Pigmented Macule - A Skin Manifestation of Invasive Breast Cancer - However, a pigmented macule that measured 5 mm in the greatest dimension was noted on the left areola (Panel A, arrow). The glands within the intradermal cancerous lesion were colonized by melanocytes with heavy deposits of melanin granules (Panel B, Fontana–Masson stain). #Clinical #Derm #Pathology #InvasiveDuctal #DuctalCarcinoma #Nipple #PigmentedMacule #Microscopy #NEJM