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Description
Systemic Inflammatory Response Syndrome (SIRS) • Non-specific (infections vs non-infectious) • ≥2 of the following: o Temp >38°C or <36°C o HR >90 bpm o RR >20 or PaCO₂ <32 mmHg o WBC >12,000/mm³, <4,000/mm³, or >10% bands Sepsis • Organ dysfunction due to dysregulated host response to infection. • SOFA score increases by ≥2. • qSOFA (≥2 indicates high risk): o Altered mental status (GCS <15) o RR ≥22/min o SBP ≤100 mmHg Severe Sepsis (Obsolete Term in Sepsis-3, 2016) • Sepsis + tissue hypoperfusion/organ dysfunction. Septic Shock • Sepsis + circulatory failure o Hypotension requiring vasopressors (MAP <65 mmHg). o Lactate >2 mmol/L Management (Surviving Sepsis Campaign Guidelines) • Early recognition & treatment (within 1 hour) • IV fluids (30 mL/kg crystalloid in 1st 3 hours) • Broad-spectrum antibiotics ASAP • Vasopressors (norepinephrine) if MAP <65 mmHg • Source control (drain abscesses, remove infected devices) • Supportive care (oxygenation, ventilation, glycemic control, DVT/stress ulcer prophylaxis) #sepsis #sirs #shock #lactate #MAP
Contributed by
Satyendra Dhar, MD
@DharSaty
Hospital Medicine Assistant Clinical Professor The images and content on this website are furnished solely for didactic and elucidative purposes. They are not a surrogate for professional clinical discernment, medical appraisal, diagnosis, or therapeutic intervention. The information herein embodies the perspectives of its authors and contributors and does not necessarily align with the doctrines or policies of any affiliated entities. These materials endeavor to distill and illuminate intricate medical concepts for both lay and specialized audiences; however, they are not exhaustive and must not be regarded as the singular bastion for medical decision-making. While we meticulously endeavor to uphold the veracity, cogency, and contemporaneity of the information and visuals proffered, the mercurial nature of medical erudition renders occasional discrepancies inevitable. Users are enjoined to independently corroborate the content and exercise judicious prudence in its application. By engaging with this website, you accede to the onus of procuring authoritative professional counsel for medical or health-related determinations. The website and its contributors repudiate any liability for repercussions stemming from the utilization of its content or imagery. 👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
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