You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc generally indicates an acute HBV infection. IgM anti-HBc is the first antibody to appear when fighting a HBV infection. The presence of IgG anti-HBc generally indicates a chronic HBV infection. Once infected with HBV, IgG anti-HBc will generally persist for life. Oftentimes total hepatitis B core antibody will be referenced because the two tests commonly run in the clinical lab are total hepatitis B core antibody and IgM anti-HBc. Total hepatitis B core antibody (anti-HBc) simply means IgM and IgG anti-HBc.


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