Thiazide

diuretics

Carbonic anhydrase

inhibitors

(e.g., acetazolamide)

Nat-Cl symport

Na and HCO;-

reabsorption

Aldosterone

antagonists

(e.g., spironolactone)

Nat channel

(indirect effect)

Loop diuretics (e.g., furosemide)

Amiloride,

#triamterene

Nat-K+-2CF symport

Na channel

(direct effect)

#NaCI reabsorption y -

> H20 reabsorption +

ECF volume y