1 Thyroglobulin synthesis

Amino acids

Carbohydrates

Peptides

Ribosomes

Capillary

Endoplasmic reticulum

Follicular cell

2 lodine uptake, hormone synthesis, and storage

SCN-

C104

NOZ

Г pool

Nat symport

(NIS)

TSH

Nat

3 Hormone secretion

Primary lysosomes with proteases

Thyroglobulin vesicle

996

Thyroglobulin

Exocytosis

Golgi apparatus

Colloid

Thyroid peroxidase

T3/T4 synthesis

(see Fig. 25.3)

TSH

Т3/T4 storage

(bound to thyroglobulin)

TSH

Endocytosis

T3

Fusion

#Thyroglobulin cleavage

lodotyrosine

dehalogenase

MIT, DIT