Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)



DILI Types:

 • Intrinsic - predictable, dose dependent injury (ie, acetaminophen/APAP)

 • Idiosyncratic - less common, only affects susceptible individuals, less consistent dose relationship, varied presentation

 • Chronic - ongoing ↑ LFTs or symptoms of liver disease 6-9 mo after DILI onset



Calculate R-Value

 • Hepatocellular or Mixed DILI

 • Cholestatic DILI



By Tina Hang, MD @TinaPhamHang via @EmoryGastroHep



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